《普通生理學(xué)和生物物理學(xué)》每季出版一次，致力于在細(xì)胞和分子水平上發(fā)表與普通生理學(xué)，生物物理學(xué)和生物化學(xué)相關(guān)的原始研究論文。該期刊的報(bào)道包括：膜生理學(xué)和生物物理學(xué)（離子通道，受體，轉(zhuǎn)運(yùn)蛋白，蛋白質(zhì) - 脂質(zhì)相互作用，表面現(xiàn)象，模型膜），細(xì)胞間和細(xì)胞內(nèi)信號(hào)傳導(dǎo)（神經(jīng)傳遞，內(nèi)分泌調(diào)節(jié)，信使，分泌機(jī)制，調(diào)節(jié)蛋白，鈣）信號(hào)通路，一氧化氮），興奮性和收縮性（神經(jīng)生理學(xué)，平滑，心肌和骨骼肌生理學(xué)，激發(fā) - 收縮耦合，細(xì)胞運(yùn)動(dòng)），細(xì)胞功能的生物物理分析（生物能量學(xué)，體積調(diào)節(jié)，熱力學(xué)，數(shù)學(xué)模型），代謝調(diào)節(jié)（酶學(xué)，ATP酶，植物和微生物代謝），藥理學(xué)，毒理學(xué)和病理學(xué)的細(xì)胞方面（受體 - 藥物相互作用，藥物和毒素對(duì)信號(hào)和調(diào)節(jié)功能的作用，自由基，脂質(zhì)過(guò)氧化，缺血預(yù)處理，鈣悖論），有關(guān)技術(shù)和方法的進(jìn)展情況。

General Physiology and Biophysics appears quarterly and is devoted to the publication of original research papers concerned with general physiology, biophysics and biochemistry at the cellular and molecular level. The coverage of the journal includes: membrane physiology and biophysics (ion channels, receptors, transporters, protein-lipid interactions, surface phenomena, model membranes), intercellular and intracellular signalling (neurotransmission, endocrine regulations, messengers, secretory mechanisms, regulatory proteins, calcium signalling pathways, nitric oxide), excitability and contractility (neurophysiology, smooth, cardiac and skeletal muscle physiology, excitation-contraction coupling, cellular motility), biophysical analysis of cellular function (bioenergetics, volume regulation, thermodynamics, mathematical models), metabolic regulations (enzymology, ATPases, plant and microbial metabolism), cellular aspects of pharmacology, toxicology and pathology (receptor-drug interaction, the action of drugs and toxins on signalling and regulatory functions, free radicals, lipid peroxidation, ischemic preconditioning, calcium paradox), accounts of advances in relevant techniques and methodology.